11th International Akademie Fresenius Conference "Endocrine Disruptors" +++ONLINE CONFERENCE+++

24.11. - 25.11.2020, Online Conference | Die Akademie Fresenius GmbH

11th International Akademie Fresenius Conference "Endocrine Disruptors" +++ONLINE CONFERENCE+++

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For many years, the Akademie Fresenius Conference “Endocrine Disruptors” has been the perfect platform for bringing together the regulatory, industrial and consulting communities. With the COVID-19 crisis, it has become difficult to gather physically. However, since we all need to continue to learn from one another, we have decided to keep up our dialogue in the virtual space. We therefore cordially invite you to join this year’s Online Conference. Plenty of exciting presentations are awaiting you! And they will all be accessible from the comfort of your home or your office, thus reducing travel on the one hand and increasing accessibility on the other hand. We are looking forward to meeting you!


  • EFSA on the ED guidance document and its implementation
  • Industry perspective on human health topics
  • Update on endocrine disruption in ecotoxicology – An industry view
  • Practical experiences with OECD 229 and OECD 231 from a laboratory point of view
  • Pharmaceuticals and their endocrine disrupting properties
  • Plurality of scientific perspectives in evaluating Endocrine Disruptors: From stumbling block to opportunity

Who do you meet?

Professionals working in the fields of:

  • Toxicology and ecotoxicology
  • Chemical risk assessment
  • Research and development
  • Regulatory affairs
  • Registration and authorisation
  • Legal and general counselling

Sectors taking part:

  • Chemical/biocide/agrochemical/pharmaceutical/cosmetic industries 
  • Research institutes
  • Regulatory authorities
  • Environmental and health risk consultants
  • Testing laboratories and contract research organisations (CROs)
  • NGOs

Picture credit: @Subbotina Anna/shutterstock.com, @chestra - Fotolia.com


PLEASE NOTE: The indicated times refer to Central European Time CET.

For further time zones, please view here.

Tuesday, 24 November 2020

10:45 CET - Start of the Online Conference

Welcome address by the organisers and introduction by the Chairs

Lennart Weltje, BASF, Germany
Emily McVey, Board for the Authorisation of Plant Protection Products and Biocides (Ctgb), The Netherlands

11:00 CET - Regulatory Developments

Overview of the EFSA assessments for pesticide active substances following the implementation of the ECHA/EFSA Guidance on the hazard identification of endocrine disruptors.

Maria Arena, European Food Safety Authority, Italy

UK experience of the EU criteria and guidance to identify endocrine disruptors

  • Information requirements for different regulatory regimes
  • Criteria for pesticides and biocides
  • Guidance – some key points
  • Some examples of how the criteria and guidance have been applied to active substances

Helen McGarry, Health and Safety Executive, Chemicals Regulation Directorate (HSE/CRD), United Kingdom

Update on regulatory developments and research projects with a focus on human health

Phillip Marx-Stölting, Federal Institute for Risk Assessment, Germany

Industry perspectives on EATS assessments

  • Technical guidance, tiered testing decision points and strategy considerations
  • Timelines and testing capacity
  • Addressing the T modality - Chemically induced thyroid tumors and species differences (ECPA funded review) - Data sufficiency for effects secondary to liver enzyme induction

Helen Tinwell, Bayer CropScience, France

Global requirements and practical implementation of the ED guidance – experiences and challenges

  • Recent regulatory developments worldwide: Europe vs the Americas and Asia
  • Dealing with the ED Guidance in practice: actives and co-formulant screening for biocides
  • Hands-on implications and recommendations on a global scale

Martina Duft, knoell, Germany

13:45 CET - Lunch break

15:00 CET - Update – Human Health  

In vitro - in vivo extrapolation of endocrine activities

Caroline Gomes and Eric Fabian, BASF, Germany

ECETOC Thyroid T4 Taskforce update: Exploring key questions around thyroid evaluations for regulatory decision making

  • Activities of the ECETOC Thyroid T4 Taskforce
  • Summary of the ECETOC expert meeting in November 2019
  • Evidence for liver enzyme inducers to induce neurodevelopmental effects in humans
  • In vivo alterations in developmental neurotoxicity endpoints with a focus on thyroid related changes

Bethany Hannas, Corteva, United States

AOPs and the potential of read-across of AOPs to non-mammals

  • The ERGO project
  • Cross-species extrapolation - bridging the gap between human toxicology and ecotoxicology
  • The thyroid axis as case study

Dries Knapen, University of Antwerp, Belgium

17:00 CET - End of the first conference day

Wednesday, 25 November 2020

10:50 CET - Start of the second day of the online conference

Opening remarks for the second conference day by the Chairs

11:00 CET Update – Ecotoxicology   

Update on Endocrine Disruption in Ecotoxicology – An Industry view

  • Challenges resulting from the adoption of the guidance for the identification of endocrine disruptors - Interpretations of the guidance and testing strategies
  • Questions and uncertainties around data sufficiency, interpretation and acceptance
  • Ambiguities over the acceptance of read-across and weight of evidence approaches for non-target organisms
  • Lack of existing data relevant to assess endocrine disrupting properties in non-target organisms

Tara Miller, Syngenta, United Kingdom

Endocrine Testing in Aquatic Vertebrates

  • Short introduction to AMA (OECD 231) and FSTRA (OECD 229)
  • Practical challenges
  • Lessons we learned so far

Marysia Tobor-Kaplon, Charles River Laboratories Den Bosch, The Netherlands

Population effects on fish: The current status of ZEOGRT validation

  • Status of the validation project
  • Results from the present ZEOGRT data package
  • Critical assessment of results and outlook

Matthias Teigeler, Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Germany

Population-relevance of adverse ED effects

Magnus Wang, WSC Scientific, Germany

13:00 CET - Lunch break

14:00 CET – Other Aspects

Environmental Assessment of pharmaceuticals with ED properties

  • Environmental (risk) assessment of pharmaceuticals in Europe and the US
  • Testing strategy
  • Lessons learned

Daphne de Roode, Charles River Laboratories Den Bosch, The Netherlands 

Plurality of Scientific Perspectives in Evaluating Endocrine Disruptors: from Stumbling Block to Opportunity

  • Introduction to scientific controversies in the social sciences
  • Distinction between different types of uncertainties (technical, methodological, epistemic and societal) and how a difference in tolerance of risk and uncertainty can feed into scientific controversies
  • Case description: scientific debate around endocrine disruptors (EDs)

Annegaaike Leopold, Calidris Environment, The Netherlands

15:10 CET End of the Conference





Maria Arena

European Food Safety Authority (EFSA), Italy

Maria Arena has a background in environmental sciences and has been working as Scientific Officer in the ecotoxicology team of the Pesticide Peer Review Unit at EFSA since 2011. In her current work she is involved in the Peer Review of the environmental risk assessment for active substances used as PPPs. Additionally, she was involved in the drafting of the ECHA/EFSA Guidance on Endocrine Disruptors (ED) and she is currently performing the assessments of the ED properties of pesticides for non-target organisms. She is also coordinating the activity of the EFSA Panel on Plant Protections Products and their Residues.


Martina Duft

knoell, Germany

Martina Duft is a Senior Expert Regulatory Ecotoxicologist at knoell Germany and is the coordinator of the knoell ED expert team and key contact for the topic endocrine disruptors. She studied biology at the Ludwig Maximilian University Munich and is holding a PhD in ecotoxicology from the JW Goethe University Frankfurt. After several years in ED related research, she has worked for over 15 years in various regulatory sectors with a focus on ecotoxicology and regulatory affairs.


Caroline Gomes

BASF, Germany

Caroline Gomes holds a PhD in in pharmacology subarea toxicology, with focus on in vivo reproductive toxicity. She is currently a Laboratory Manager in the Experimental Toxicology and Ecology Department at BASF in Germany, where she previously held positions as Post-Doctoral Researcher and Trainee in the area of alternative methods to animal testing. Since 2018 she is study director of in vitro assays to assess test substances interference with steroid hormones (ERTA, ARTA and Steroidogenesis assays).


Bethany Hannas

Corteva Agriscience, United States

Bethany Hannas is a Senior Toxicologist at Corteva Agriscience. Her work focuses on developmental and reproductive toxicology and endocrine testing. She provides technical consulting support for Corteva’s laboratory and regulatory groups. She is a member of several US and EU-based industry groups and cross-sector collaborations active in these areas.


Dries Knapen

University of Antwerp, Belgium

Dries Knapen currently is an Associate Professor at the department of Veterinary Sciences of the University of Antwerp (Belgium), lecturing Biochemistry, Environmental Chemistry and Systems Biology. His research includes the fundamental study of zebrafish embryonic development, the mechanisms underlying aquatic toxicity, the development of alternative, non-animal test methods for ecological and human risk assessment, and the development of Adverse Outcome Pathways (AOPs) in predictive ecotoxicology and pharmacology.


Annegaaike Leopold

Calidris Environment, The Netherlands

Annegaaike Leopold is a Biologist by training and has 30 years of experience in the applied regulatory ecotoxicology field. She has contributed to environmental endocrine disruptor test guidelines and has worked on hazard and risk assessment of endocrine disruptors in the contract laboratory context both in research and guideline development as well as in business development and project management. She currently has her own consultancy firm working both on environmental endocrine regulatory projects and doing research in the area for science for policy - focusing on contributing to greater transparency in scientific processes to help society (regulators, policy-makers, scientists, concerned citizens) grapple with the different types of uncertainties built into the regulatory system of chemicals assessment.


Philip Marx-Stölting

Federal Institute for Risk Assessment (BfR), Germany

Philip Marx-Stölting completed a paramedic education and holds a PhD in biochemistry/toxicology. He is currently employed at the German Federal Institute for Risk Assessment (BfR), where he is head of the project group ‘Testing and assessment strategies pesticides’ and head of the BfR working group on endocrine disruptors. He is a specialist in toxicology (Fachtoxikologe, DGPT) and an Eurotox registered toxicologist (ERT).


Helen McGarry

Health and Safety Executive, Chemicals Regulation Directorate (HSE/CRD)

Helen McGarry is a Senior Regulatory Toxicologist in the UK Health and Safety Executive’s Chemicals Regulation Division. Helen has wide experience in the regulation of chemicals under the pesticides, biocides, REACH and CLP regimes.


Emily McVey

Board for the Authorisation of Plant Protection Products and Biocides (Ctgb), The Netherlands

Emily McVey is an experienced Regulatory Toxicologist and works as a Risk Assessor in ecotoxicology at the Ctgb. Her specialties include environmental toxicology, wild vertebrates (birds, mammals, amphibians, fish), molecular mechanisms of toxicity, neurodevelopmental toxicity and endocrine disruption testing and assessment.


Tara Miller

Syngenta, United Kingdom

Tara Miller is an Environmental Toxicologist at Syngenta, specialising in endocrine disruption. She completed a PhD in Aquatic Ecotoxicology in 2016, with her research centering around the effects of endocrine disrupting compounds and their mixtures on fish reproduction and endocrine function. She held a postdoctoral research position at the Natural History Museum in London working in the field of microbial genomics and microparasite diversity, before returning to ecotoxicology in July 2019 with her current role at Syngenta.


Matthias Teigeler

Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Germany

Matthias Teigeler is currently heading the department Ecotoxicology at the German Fraunhofer Institute for Molecular Biology and Applied Ecology IME. His work focuses on the long-term effects of endocrine acting chemicals on fish populations. Current topics of his team intend to include new test parameters and the improvement of existing guidelines.


Helen Tinwell

Bayer Crop Science Division, France

Helen Tinwell has a PhD in genotoxicity and joined Bayer Crop Science in 2005 after having spent 17 years at Syngenta. Until recently, she has worked in research toxicology focusing on method development and mode of action investigations to address endocrine disruption. In 2017 she became team leader of the Regulatory Toxicology group. She leads the development and application of testing strategies for evaluating potential endocrine-disrupting properties of plant protection molecules in mammals and is a member of the ECPA ED Expert Group.


Marysia Tobor-Kaplon

Charles River Laboratories Den Bosch BV, The Netherlands

Marysia Tobor-Kaplon is currently working as a Study Director at the section of Environmental Sciences of Charles River in Den Bosch. She is a member of Endocrine Disruption Expert Team. She obtained her PhD in Environmental Sciences from the University in Utrecht.


Magnus Wang

WSC Scientific, Germany

Magnus Wang is the Managing Director of WSC Scientific. He has previously been Head of the department Environmental fate & Modelling at Rifcon and held a post doc position at the University of Seville in Spain.


Lennart Weltje

BASF, Germany

Lennart Weltje holds a PhD in ecotoxicology and environmental chemistry and currently works as a Senior Ecotoxicologist at BASF conducting risk assessments for PPPs and biocides. He is also an honorary Professor at the Faculty of Agricultural Sciences of the Georg-August University in Goettingen. His former stations include the Dutch National Institute for Public Health and the Environment (RIVM).

de Roode

Daphne de Roode

Charles River Laboratories Den Bosch BV, The Netherlands

Daphne de Roode has been working for Charles River since 2002. She worked as a study director in aquatic ecotoxicology before being engaged in Regulatory Affairs as a (senior) regulatory ecotoxicologist and environmental fate specialist. Daphne has extensive experience in dossier preparation as well as in conducting and reporting environmental risk assessments in a variety of legal frameworks, including pharmaceuticals for human use. Since 2019, Daphne leads the section of Regulatory Environmental Toxicology and Chemistry within the Regulatory Affairs department.



Online Conference | Die Akademie Fresenius GmbH
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Teilnahmepreis: € 795,00 zzgl. MwSt.

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