2nd International Fresenius MIXTOX Conference "Toxicity of Chemical Mixtures: Risk, Hazard and Exposure Assessment"

08.06. - 09.06.2017, Park Inn by Radisson Köln City West, Cologne/Germany

2nd International Fresenius MIXTOX Conference "Toxicity of Chemical Mixtures: Risk, Hazard and Exposure Assessment"

Übersicht Programm Referenten Veranstaltungsort Preise & Leistungen



EU Guidance

  • Risk management: Cumulative risk assessment for dietary risk assessment of pesticides (DG SANCO)
  • European Commission’s (DG ENV) perspective on mixture toxicity
  • The European Commission‘s Joint Research Centre on mixture toxicity

Latest from regulators and industry

  • Cumulative risk assessment of regulated substances – dietary exposure and nondietary exposure
  • Cumulative risk assessment of pesticides for operator and worker risk assessment
  • Environmental risk assessment and mixture toxicity for biocides and pesticides
  • ECHA’s current activities regarding mixture toxicity for REACh chemicals and biocides
  • EFSA’s vision of harmonisation of ERA and human toxicology

Testing approaches and international research projects

  • Update on the EuroMix project
  • The WHO Framework: Implications for combined exposures assessment
  • Update on EDC-MixRisk project
  • A perspective on cumulative risk assessment that is protective of human health yet resource-efficient

Who do you meet?

Groups that should take part:

Professionals working in the fields of

  • Ecotoxicology/Environment
  • Toxicology
  • Hazard, exposure and risk assessment for human health and the environment
  • Field studies
  • Modelling
  • Regulatory affairs
  • Registration

Sectors that should take part: 

  • Agrochemical industry
  • Biocidal products producers
  • Chemical industry
  • Research institutes
  • Authorities (registration and control authorities)
  • Scientific consulting in the area of (eco-)toxicology as well as environmental fate and behaviour
  • Authorities 
  • Professional associations

Picture credit: © Irochka - Fotolia.com


Get-Together on Wednesday, 7 June 2017

Will you arrive on Wednesday?
Come to the hotel bar at 8 p.m. and meet other participants and experts in a relaxed atmosphere.

Thursday, 8 June 2017

8.00 Registration and coffee

8.30 Welcome address by the Akademie Fresenius and introduction by the Chair
Tina Mehta
, Dow AgroSciences/ECPA Toxicology Expert Group (TEG), United Kingdom

Cumulative Risk Assessment – Dietary Exposure

8.40 Regulatory perspective on cumulative dietary risk assessment of pesticides

Philip Marx-Stölting, Federal Institute for Risk Assessment (BfR), Germany

9.05 Industry perspective on cumulative risk assessment for dietary risk assessment of pesticides

  • Results of a re-assessment of the thyroid and the nervous system: CAGs proposed by EFSA
  • Elements of potency of adverse effects and realistic and likely exposures of pesticides need to be considered for cumulative risk assessment
  • First outline of an industry-sponsored scientific project on manageable cumulative risk assessment

Stephanie Melching-Kollmuss, BASF/ ECPA Working Group on Cumulative Risk Assessment, Germany

9.30 Cumulative risk assessment for dietary exposure to pesticides residues – state of play on the implementation in European decision making

Veerle Vanheusden, European Commission, Belgium

9.55 Panel discussion
10.25 Coffee break

Cumulative Risk Assessment – Non-dietary Exposure

10.55 Non-dietary cumulative risk assessment – where to start?

  • The topic of non-dietary cumulative risk assessment is highly complex and needs to be addressed but how?
  • An agronomic based approach has been developed to provide a realistic assessment arena
  • The approach is presented and future work/refinement discussed

Alistair Morriss, Dow AgroSciences, United Kingdom

11.20 Member State perspective on cumulative risk assessment of pesticides for non-dietary risk assessment

  • What do we do now and is that enough?
  • What does the data tell us so far and what do we still require? Which tools are available?
  • Further challenges and opportunities?

Susanne Hougaard Bennekou, Danish Environmental Protection Agency (EPA), Denmark

11.45 Panel discussion
12.15 Lunch

Environmental Risk Assessment and Mixture Toxicity

13.15 EFSA’s vision of harmonisation of ERA and human toxicology

Christer Hogstrand, King‘s College London/EFSA MixRisk Working Group, United Kingdom

13.40 Mapping the environmental risks of pesticides: Present and future

  • Assessing aggregate exposures from different applications
  • Assessing combined risks on different non-target organisms for multiple applications
  • Assessing the overall environmental impact of pesticides

Representative of EFSA, European Food Safety Authority (EFSA), Italy

14.05 Short break

14.20 Joint contribution: European Commission (DG ENV) perspective on mixture toxicity

  • Update on mixtures work across the Commission
  • Investigating the possibility of regulating mixture toxicity in surface waters

Helen Clayton / Peter Korytar, European Commission, Belgium

15.00 Mixture toxicity and ecological risk assessment of plant protection products

  • Regulatory requirements and guidance for risk assessment
  • Testing requirements – what do we need to test and why? Is it effective? Are we missing anything?

Mick Hamer, Syngenta, United Kingdom

15.25 Panel discussion
15.55 Coffee break

16.25 The SETAC Pellston workshop on simplifying environmental mixtures: Pareto-type prioritisations of impacted sites and risky compounds

Leo Posthuma, National Institute for Public Health and the Environment (RIVM), The Netherlands

16.50 Overview: ECHA’s current activities regarding mixture toxicity for REACh chemicals and biocides

Simon Gutierrez, European Chemicals Agency (ECHA), Finland

17.15 Environmental risk assessment of biocides: Current development of guidance on mixture toxicity and substances of concern

Anja Kehrer, Federal Environment Agency (UBA), Germany

17.40 Panel discussion

18.10 End of the first day

19.10 Departure time for the evening event
At the end of the first conference day, Akademie Fresenius invites you to a leisurely evening in Cologne. After a short city walking tour, we will have dinner at a traditional brewpub with local beer. Don‘t miss out on this opportunity!

Friday, 9 June 2017

8.30 Welcome address by the Chair
Martin Wilks
, Swiss Centre for Applied Human Toxicology, Switzerland

Testing Approaches and Research Projects

8.40 How can mixture testing refine future European risk assessment? The EuroMix project

  • State of the art European mixture risk assessment
  • EuroMix test strategy
  • How test results can be linked to future risk assessment

Jacob van Klaveren, National Institute for Public Health and the Environment (RIVM), The Netherlands

9.05 The WHO Combined Exposures Framework: Implications for assessment and application

  • Recent experience with the WHO Framework on Combined Exposures
  • An example of practical application in the development of guidelines
  • Discussion of the implications

Bette Meek, University of Ottawa, Canada

9.30 EDC-MixRisk – a novel approach for assessing EDCs

  • Epidemiology in two child cohorts, one in Sweden, one in Germany
  • Experimental systems
  • Risk assessment and societal impact

Åke Bergman, Swedish Toxicology Sciences Research Center/Karolinska Institutet, Sweden

9.55 The European Human Biomonitoring Initiative HBM4EU – an outlook

Erik Lebret, National Institute for Public Health and the Environment (RIVM), The Netherlands

10.20 Panel discussion
10.50 Coffee break

11.20 A perspective on cumulative risk assessment that is protective of human health yet resource efficient

  • Problem formulation
  • Tiered approaches
  • Basis for grouping chemicals
  • Use of information on AOPs

Alan R. Boobis, Imperial College London, Division of Medicine, United Kingdom

11.45 Update on the OECD’s Combined Exposure Project

  • Brief overview of OECD’s hazard assessment programme activities
  • Combined Exposure Project
  • Considerations for problem formulation and scoping, hazard, exposure and risk assessment

Eeva Leinala, The Organisation for Economic Co-operation and Development (OECD), France

12.10 Current approaches and future perspectives for the hazard and risk assessment of chemical mixtures

  • Current practices in assessing mixtures: lessons learned from existing case studies and an expert survey
  • Use of novel tools for the hazard assessment of mixtures

Stephanie Bopp, EU Commission’s Joint Research Centre (JRC), Italy

12.35 Panel discussion

13.05 Final remarks

13.35 Lunch and end of the conference





Åke Bergman

Swedish Toxicology Sciences Research Center / Karolinska Institutet, Sweden

Åke Bergman is Executive Director of Swetox Research Center and the Head of Unit of Toxicology Sciences at Karolinska Institutet. He has also served as Professor for Environmental Chemistry at Stockholm University since 1993 and as Guest Professor at Tongji University in Shanghai since 2012. Åke has also served at numerous national and international expert groups and review panels, such as the UNEP/WHO program panel for EDs.


Alan R. Boobis

Imperial College London, Division of Medicine, United Kingdom

Alan R. Boobis is Professor of Biochemical Pharmacology at Imperial College London and Director of the Toxicology Unit (supported by Public Health England and the Department of Health). He has been a member of the EFSA PPR Panel and the Panel on Contaminants in the Food Chain. He is chair/member of the FAO/WHO Joint Meeting on Pesticide Residues, chair/member of the Joint FAO/ WHO Expert Committee on Food Additives (residues of veterinary drugs) and chair of the UK Committee on Toxicity.


Stephanie Bopp

European Commission JRC, Italy

Stephanie Bopp (PhD) works as Scientific Officer at the European Commission’s Joint Research Centre (JRC), where she is leading the activities on the assessment of chemical mixtures. Having collected much experience whilst working for several other organisations in the area of ecotoxicology and environmental chemistry, in her last role before the JRC, she worked for EFSA, where her focus was on pesticide risk assessment.


Helen Clayton

European Commission, Belgium

Helen Clayton has been a Policy Officer in DG ENV for 8 1/2 years. Since 2010 she is responsible for implementing the Water Framework Directive within the DG’s ‘Water unit’. Her focus is chemical pollutants in surface waters. She is leading ENV's work with DG SANTE on the Commission's strategic approach to pharmaceuticals in the environment. A general scientist by training with a PhD in plant biochemistry she has also worked as a Patent Examiner, and in a science-to-policy role for the UK research councils.


Simon Gutierrez

European Chemicals Agency (ECHA), Finland

Simon Gutierrez is an Ecotoxicologist by training with more than 10 years of experience in the field of ecotoxicology, environmental risk assessment and regulatory issues. He has a wide experience in biocides both in the public and private sector. Simon is currently Team Leader of the environmental team in the biocides unit in ECHA and is Deputy-Chair of the Environmental Working Group of the BPC at ECHA.


Mick Hamer

Syngenta, United Kingdom

Mick Hamer has almost 40 years’ experience working for Syngenta and its legacy companies in the field of ecotoxicology, environmental fate and risk assessment. He is member of the CEFIC Mixtures industry ad-hoc team (MIAT) and Organizer of the 2015 SETAC Pellston workshop on simplifying environmental mixtures.


Christer Hogstrand

King's College London, United Kingdom

Christer Hogstrand is a Professor at the Diabetes & Nutritional Sciences Division at King’s college London. Besides this role, he is an Expert for the European Food Safety Authority (EFSA) and currently a member on its Panel on Contaminants in the Food Chain. He has been involved in 12 EFSA working groups and is presently chairing three, including its working group on Chemical Mixtures.

Hougaard Bennekou

Susanne Hougaard Bennekou

Danish Environmental Protection Agency (EPA), Denmark

Susanne Hougaard Bennekou is a Regulatory Toxicologist in the Pesticide Division of the Danish EPA. She is Vice-Chair of EFSA’s PPR panel and has been involved in developing methodologies for Cumulative Risk Assessment of pesticides. Currently, she is involved in developing the EFSA guidance document for harmonisation of risk assessment methodologies for human health and ecological risk assessment of combined exposure to multiple chemicals. She is also involved in the H2020 supported project “EU-ToxRisk”, which aims at driving mechanism-based toxicity testing and risk assessment.


Anja Kehrer

Federal Environment Agency (UBA), Germany

Anja Kehrer works as a Scientific Officer within the field of environmental risk assessment of biocides at the German Environment Agency (UBA), where she is responsible for the environmental risk assessment of biocidal active substances and products in the context of the directive 98/8/EC and regulation 528/2012. During her diploma- and PhD-thesis she focused on ecotoxicology and investigated mixtures of chemicals.


Erik Lebret

National Institute for Public Health and the Environment (RIVM), The Netherlands

Erik Lebret is Chief Science Officer for "integrated risk assessment" at RIVM. In addition, as Endowed Professor, he also works for the Institute for Risk Assessment Sciences (IRAS) at Utrecht University on Environmental Health Impact Assessment. Besides his role at RIVM he regularly participates in expert and advisory committees. Currently he is a member of management board of the European Biomonitoring initiative HBM4EU, where his work is dedicated to chemical mixtures.


Eeva Leinala

Organisation for Economic Co-operation and Development (OECD), France

Eeva Leinala (PhD) is a Principal Administrator in the Environment Health and Safety Division of the OECD, where she advances projects related to risk assessment and risk reduction of chemicals. She is the Principal Administrator for both the Hazard Assessment Programme and the Risk Reduction Programme. Prior to the OECD she worked in the area of chemical risk assessment at Health Canada for 12 years.


Bette Meek

University of Ottawa, Canada

Bette Meek has a background in toxicology and is currently the Associate Director of Chemical Risk Assessment at the McLaughlin Centre for Risk Science, University of Ottawa. She previously managed several chemical risk assessment programs within Health Canada.


Tina Mehta

Dow AgroSciences, United Kingdom

Tina Mehta has worked for Dow AgroSciences for 15 years in Human Health Assessment and is currently the EMEA/APAC Toxicology/ Risk Assessment Leader. She is also the EU Leader for dietary risk assessment and global focal point for cumulative risk assessment. She is a member of ECPA Toxicology Expert Group (TEG) and Joint-Toxicology, Residue ad hoc Group (J-TRAG). Tina is also leading industry efforts on implementation of agrochemical exposure-driven assessments.


Stephanie Melching-Kollmuss

European Crop Protection Association (ECPA), Belgium

Stephanie Melching-Kollmuss has been working as European and Global Regulatory Toxicologist for plant protection products at BASF since 2006. Her main research interest is combined toxicity assessment and she continues to be involved in ECETOC and CEFIC LRI projects. She is a member of ECPA working groups on cumulative risk assessment.


Alistair Morriss

Dow AgroSciences, United Kingdom

Alistair Morriss is a Risk Assessor, in the Human Health Assessment team at Dow AgroSciences in the UK since 2010. Prior to this he worked in contract research organisations for 8 years specialising in operator exposure studies as well as residue and environmental fate studies. He is Chairman of the ECPA OBEEG and a member of the CLI OPEX group.


Leo Posthuma

National Institute for Public Health and the Environment (RIVM) / Radboud University, The Netherlands

Leo Posthuma is a Senior Scientist at RIVM’s Centre for Sustainability, Environment and Health and a Registered EUROTOX Toxicologist. Since 2016 he has been a Professor for “Sustainability and Environmental Risks” at Radboud University Nijmegen. His previous roles at RIVM included Head, Dpt. of Soils and Sediments and Senior Scientist at the Laboratory for Ecological Risk Assessment.


Veerle Vanheusden

European Commission, Belgium

Veerle Vanheusden is a Policy Officer for “Pesticides and Biocides” in DG SANTE of the European Commission. Her areas of activity include legislation for cumulative risk assessment of pesticides residues, pesticides residues monitoring, reviewing the existing maximum residue levels and the coordination of the European reference laboratories for pesticides. She has previously worked in the private pharmaceutical sector (organic chemistry and analytical chemistry).


Martin Wilks

University of Basel,Swiss Centre for Applied Human Toxicology, Switzerland

Martin Wilks is a Medical Toxicologist and risk assessment expert with more than 25 years of experience in academia, industry and the health service. He is Director of the Swiss Centre for Applied Human Toxicology (SCAHT) and Adjunct Professor at the Medical Faculty of the University of Geneva. He is a EUROTOX Registered Toxicologist, a Fellow of the Royal College of Physicians of Edinburgh and President-elect of the European Associations of Poisons Centres and Clinical Toxicologists.

van Klaveren

Jacob van Klaveren

National Institute for Public Health and the Environment (RIVM), The Netherlands

Jacob van Klaveren has worked for RIVM as Senior Scientific Advisor since 2010. He coordinated the EU funded ACROPOLIS project and is currently in charge of coordinating the EFSA-RIVM partnership on the follow-up ACROPOLIS and the H2020 EuroMix project, which is a new strategy for mixture testing.” Since 2016, Jacob is a Guest Professor at the Danish Technical University.



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