3rd International Akademie Fresenius MIXTOX Conference "Toxicity of Chemical Mixtures: Risk, Hazard and Exposure Assessment"

29.10. - 30.10.2019, Park Inn by Radisson Köln City West, Cologne/Germany

3rd International Akademie Fresenius MIXTOX Conference "Toxicity of Chemical Mixtures: Risk, Hazard and Exposure Assessment"

Übersicht Programm Referenten Veranstaltungsort Preise & Leistungen

Übersicht

Programme update: Late-breaking EFSA presentation on cumulative risk assessment of pesticide residues in food!

Highlights

Risk Management and Communication

  • EU Commission on risk management approaches in assessing the cumulative risk of combined dietary exposure to pesticide residues
  • Health Canada on their cumulative health risk assessment approach for pesticides
  • Lay people’s toxicology and how heuristics influence perceptions

Risk Assessment

  • EFSA's pilot cumulative risk assessments of pesticide residues
  • Latest activities of JMPR and JECFA
  • OECD document on assessing the risks of combined exposures to multiple chemicals and way forward
  • Industry activities on cumulative risk assessment of pesticide residues

Exposure Assessment

  • Probabilistic exposure modelling in cosmetics, pesticides and food
  • Ineris: PBPK modelling for assessing exposure to chemical mixtures
  • An exposome approach to mixtures

Hazard Assessment

  • Grouping active substances in cumulative assessment groups – EFSA and ECPA approach
  • Using (Q)SARs, TTC, molecular docking simulation and read-across
  • Mixture effects at low doses and implications for biomonitoring and risk assessments in regulatory practice

Who do you meet?

Professionals working in the fields of:

  • Toxicology
  • Hazard, exposure and risk assessment for human health 
  • Modelling
  • Regulatory affairs
  • Registration and authorisation
  • Scientific advisory
  • Product safety

Sectors taking part: 

  • Agrochemical industry
  • Biocidal products producers
  • Chemical industry
  • Research institutes
  • Authorities
  • Scientific consultancies in the area of toxicology
  • Professional associations
  • NGOs

Picture credit: © Irochka - Fotolia.com

 

 

Programm

Get-together on Monday, 28 October 2019

Will you arrive on Monday? Come into the hotel bar at 8 p.m. and meet other participants and experts in a relaxed atmosphere.

Tuesday, 29 October 2019

8.30 Registration and coffee
9.00 Welcome address by Akademie Fresenius and introduction by the Chair
Martin Wilks,
Swiss Centre for Applied Human Toxicology, Switzerland

9.10 Risk assessment of combined exposures to multiple chemicals – keynote on a harmonised implementation

  • Overview of the current regulatory requirements for risk assessment of chemical mixtures
  • Existing methodologies and guidance for assessing risks from combined exposure to multiple chemicals and remaining gaps
  • Recommendations for an internationally harmonised implementation of the risk assessment of combined exposure to multiple chemicals

Stefanie Rotter, German Federal Institute for Risk Assessment (BfR), Germany

9.35 The EuroMix project and implementation of cumulative risk assessment of pesticides in Europe

  • EFSA-RIVM partnership results
  • How EuroMix model and data platform (MCRA) can be used by user groups
  • Future test strategy to generate missing hazard data

Jacob van Klaveren, National Institute for Public Health and the Environment (RIVM), The Netherlands

10.00 Results of the EDC-MixRisk project

  • Epidemiological analysis
  • Interaction between epidemiology and experimental toxicology
  • Novel whole mixture approach

Carl-Gustaf Bornehag, Karlstad University, Sweden

10.25 Coffee break

Hazard Assessment

10.55 EuroMix: using (Q)SARs, TTC, molecular docking simulation and read-across as first tier approaches in mixture toxicity risk assessment

  • Grouping and (relative) potency of components for quantitative calculation of mixture risk
  • QSARs and molecular docking for cumulative assessment group membership
  • Read-across, molecular docking or TTC for potency

Emiel Rorije, National Institute for Public Health and the Environment (RIVM), The Netherlands

11.20 Grouping active substances in cumulative assessment groups (CAG) for effects on the liver, reproductive and developmental toxicity – what does matter?

  • Overview of current EFSA approaches in grouping active substances for cumulative risk assessment
  • Analysis of possible CAG refinements to reduce complexity and duplicity
  • Examples of chemical allocation to liver and reproductive/developmental toxicity CAG based on ECPA approach

Giovanna Semino-Beninel, Bayer, France

11.45 Mixture effects at low doses and implications for biomonitoring and risk assessments in regulatory practice

  • Key experiments with a focus on genotoxic chemicals
  • Examples of application
  • Implications for biomonitoring and regulation
  • Update on the HBM4EU project

Andreas Kortenkamp, Brunel University London, United Kingdom

12.25 Panel discussion

13.00 Lunch

Exposure Assessment

14.30 Exposure assessment at the work place

  • Exposure to mixtures and chemical products for workplace risk assessment
  • Assessment of mixtures in regulatory frameworks
  • Research and development for mixtures and complex substances: some examples

Urs Schlüter, German Federal Institute for Occupational Safety and Health (BAuA), Germany

14.55 Modelling exposure to pesticide mixtures from dietary and crop spray sources in UK residents, using the EuroMix tool

  • EuroMix software for combining dietary and non-dietary exposure sources
  • Case study: combining the UK Pesticide Usage Survey with simulated exposure levels from the EU-funded Browse model

Marc Kennedy, Fera Science, United Kingdom

15.20 Coffee break

15.50 Probabilistic exposure modelling in cosmetics, pesticides and food

  • Probabilistic exposure estimates versus worst case scenario type deterministic computation
  • Fragrance exposure from cosmetics and personal care products
  • Pesticide and nutrition exposure

John O’Brien, Creme Global, Ireland

16.15 PBPK modelling for assessing the exposure to chemical mixtures

  • The PBPK model in MCRA to assess internal exposure and perform extrapolations
  • Assessing the exposure to pyrethroids mixtures using multi-route PBPK models and human biomonitoring data

Céline Brochot, French National Institute for Industrial Environment and Risks (Ineris), France

16.40 Risk assessment of combined exposure to multiple chemicals in EFSA - Experience gained and lessons learned

  • Outcome of the pilot assessment for pesticides
  • Overview of other ongoing generic activities
  • Future alignment across domains and Member States

Bruno Dujardin, European Food Safety Authority (EFSA), Italy

17.05 Panel discussion

17.35 End of first day

18.45 Departure time for the evening event

At the end of the first conference day Akademie Fresenius invites you to a leisurely evening at the brewery “Gilden im Zims” in Cologne. You have the opportunity of better getting to know other participants you met during the day over a relaxed meal. Don't miss out on this opportunity!

Wednesday, 30 October 2019

9.00 Welcome address by the Chair
Stephanie Melching-Kollmuss
, BASF, Germany

Risk Assessment

9.10 Global harmonisation of the approach to risk assessment of combined exposures: the role and activities of FAO/WHO JMPR and JECFA

  • How to assess exposure on a global perspective
  • How to identify the substances of concern
  • First actions taken by JMPR and JECFA

Angelo Moretto, University of Milan/International Centre for Pesticides and Health Risk Prevention (ICPS), Italy

9.35 OECD document “Considerations for assessing the risks of combined exposures to multiple chemicals"

  • Overview of the document
  • Problem formulation and scoping
  • Characterisation of hazard, exposure and risk
  • Follow-up activities and possible way forward

Takaaki Ito, Organisation for Economic Co-operation and Development (OECD)

10.00 Cumulative risk assessment of pesticide residues – industry activities

  • Examples of deterministic and probabilistic assessments based on monitoring data
  • Identification of risk drivers
  • Uncertainties inherent to the assessment and how to reduce them

Frank Laporte, Bayer, France

10.25 Panel discussion

10.55 Coffee break

Risk Management and Communication

11.25 EU risk management approaches in assessing cumulative risk of combined dietary exposure to pesticide residues

  • Cumulative risk assessment in the current EU pesticide and biocide regulations
  • Retrospective cumulative risk assessment: assumptions and conclusions
  • Prospective cumulative risk assessment: the challenges
  • EU decision making options

Stephanos Kirkagaslis, European Commission, Belgium

11.50 Health Canada’s framework for cumulative health risk assessment of pesticides

  • Overview of the framework published by Health Canada’s Pest Management Regulatory Agency in 2018
  • Discussion of the approach and current status of cumulative health risk assessments of pesticides in Canada

Katie Calp, Health Canada’s Pest Management Regulatory Agency (PMRA), Canada

12.15 Lay people’s toxicology: heuristics influence perceptions

  • Intuitive toxicology
  • How simple heuristics cause biased decisions
  • Lack of knowledge and people’s chemophobia

Michael Siegrist, ETH Zürich, Switzerland

12.40 Panel discussion

13.10 Lunch and end of the conference


Referenten

 

 

Name

Unternehmen

Bornehag

Carl-Gustaf Bornehag

Karlstad University, Sweden

Carl-Gustaf Bornehag is an Environmental Epidemiologist and Professor and Head of Public Health Sciences at the Department of Health at Karlstad University and Adjunct Professor at Icahn School of Medicine at Mount Sinai. His research focus is on early life exposure for environmental factors such as endocrine disrupting chemicals (EDCs) and the importance for children´s health and development. He is principal investigator for the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study.

mehrweniger
Brochot

Céline Brochot

French National Institute for Industrial Environment and Risks (Ineris), France

Céline Brochot works at the French National Institute for Industrial Environment and Risks (Ineris) and is an expert in toxicokinetic modelling and risk assessment. She has 15 years of experience in the fields of physiologically based pharmacokinetic models, exposure assessment and quantitative in vitro/in vivo extrapolations for toxicokinetics. She leads or has led toxicokinetic modelling activities in several European projects on integrated risk assessment (2FUN, 4FUN and OBERON) and on exposure assessment (HELIX and HBM4EU) and is an expert for the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) on toxicokinetic modelling.

mehrweniger
Calp

Katie Calp

Health Canada's Pest Management Regulatory Agency (PMRA), Canada

Katie Calp has been working in the field of regulatory toxicology for Health Canada’s Pest Management Regulatory Agency (PMRA) since 2002 and currently manages a team responsible for the toxicology reevaluation of post-market pesticides in support of human health risk assessment. She was involved in the development of the PMRA’s recently published cumulative health risk assessment framework and continues to play a key role in its implementation.

mehrweniger
Dujardin

Bruno Dujardin

European Food Safety Authority (EFSA), Italy

Bruno Dujardin is a Senior Scientific Officer at EFSA dealing with exposure assessment. He provides horizontal support to EFSA's scientific units and panels for the assessment of dietary exposure to chemicals in food or feed and has many years of experience in pesticide residue risk assessment. Before joining EFSA, he worked for the Federal Public Service for Public Health, Food Chain Safety and Environment in Belgium.

mehrweniger
Ito

Takaaki Ito

Organisation for Economic Co-operation and Development (OECD)

Takaaki Ito is an Administrator in the Environment, Health and Safety Division of the OECD. He advances projects on exposure assessment of chemicals, Pollutant Release and Transfer Register (PRTR) and Best Available Techniques (BAT) for preventing and controlling industrial pollution. He previously worked at Ministry of the Environment Japan for 14 years.

mehrweniger
Kennedy

Marc Kennedy

Fera Science, United Kingdom

Marc Kennedy is a Statistician working at Fera Science with over 25 years’ experience developing probabilistic methods and software. He has worked on several EU projects including the ACROPOLIS and EuroMix projects for aggregate and cumulative exposure assessments, and the Browse project to simulate bystander, resident, operator and worker exposures. He has served as an expert for EFSA and ILSI-Europe.

mehrweniger
Kirkagaslis

Stephanos Kirkagaslis

European Commission, Belgium

Stephanos Kirkagaslis works at the European Commission (DG SANTE) as Policy Officer for pesticide residues. He deals with MRL reviews, the EU multi-annual control programme, developments in cumulative risk assessment and the working programmes of the EU Reference Laboratories. He served the agricultural sector and the food industry for 11 years as QA/QC manager and as food safety/hygiene auditor (ISO 9K, 22K, BRC, GlobalGAP) for multinational companies and certification bodies in Europe and the Middle East.

mehrweniger
Kortenkamp

Andreas Kortenkamp

Brunel University London, United Kingdom

Andreas Kortenkamp is Professor for human toxicology at the Institute of Environment, Health and Societies at Brunel University London. Among other involvements he has produced the State of the Art Report on Mixture Toxicology for the European Commission. He was also involved with several working groups of EFSA on developing grouping criteria for mixture risk assessment for pesticides.

mehrweniger
Laporte

Frank Laporte

Bayer, France

Frank Laporte holds a PhD in organic chemistry and has been working in residue chemistry and dietary risk assessment at Bayer (and predecessor companies) since 1999. He participated in the development of the OECD MRL calculator and the evaluation of the proportionality concept between application rates and residue levels. He is currently involved in the revision of the OECD Guidance Document on the definition of residue and is member of the ECPA Expert Groups on cumulative risk assessment and residue definition.

mehrweniger
Melching-Kollmuss

Stephanie Melching-Kollmuss

BASF, Germany

Stephanie Melching-Kollmuss has been working as European and Global Regulatory Toxicologist for plant protection products at BASF since 2006. Her main research interest is endocrine disruption and combined toxicity assessment and she continues to be involved in ECETOC and Cefic LRI projects on mixture and combination toxicity projects. She is member of the ECPA Endocrine Disruption Expert Group and chairs the Cumulative Risk Assessment subgroup of ECPA. She was involved as a Scientific Advisory Board Member in the EuroMix Project.

mehrweniger
Moretto

Angelo Moretto

University of Milan/International Centre for Pesticides and Health Risk Prevention (ICPS), Italy

Angelo Moretto is Professor of ocupational medicine at the Department of Biomedical and Clinical Sciences at the University of Milan as well as the Director of the International Centre for Pesticides and Health Risks Prevention (ICPS). He has been involved in the risk assessment of chemicals, especially of pesticides for many years including the risk assessment of combined exposures within JMPR, EFSA and the EuroMix project.

mehrweniger
O'Brien

John O'Brien

Creme Global, Ireland

John O'Brien is the Head of Data Modelling and Statistics in Creme Global. His background are areas such as molecular biology, bioinformatics, genomics, and analysis of clinical trial data.

mehrweniger
Rorije

Emiel Rorije

National Institute for Public Health and the Environment (RIVM), The Netherlands

Emiel Rorije has been working as Senior Risk Assessor Toxicology for the Dutch National Institute for Public Health and the Environment (RIVM) since 2005. He graduated in (theoretical) chemistry and has been working on (toxicological) QSAR evaluation and development in academia (University of Utrecht), government (RIVM) as well as industry (BASF). At BASF his working area was the prediction of metabolism and (bio)degradation whereas he is currently also focusing on human toxicological structure-activity models and alternatives for in-vivo animal testing.

mehrweniger
Rotter

Stefanie Rotter

German Federal Institute for Risk Assessment (BfR), Germany

Stefanie Rotter is a Biologist and has been working as Research Assistant in the Department Pesticides Safety of the German Federal Institute for Risk Assessment (BfR) since 2015. Her work primarily concerns regulatory aspects and new methodologies for risk assessment of combined exposure to multiple chemicals and their implementation.

mehrweniger
Schlüter

Urs Schlüter

Federal Institute for Occupational Safety and Health (BAuA), Germany

Urs Schlüter holds a PhD in chemistry and started his career in 2002 at the Federal German Federal Institute for Occupational Safety and Health (BAuA) where he is heading the group "Exposure Scenarios" dealing with occupational exposure assessment. He is also a member of the ECHA Committee for Risk Assessment (RAC).

mehrweniger
Semino-Beninel

Giovanna Semino-Beninel

Bayer, France

Giovanna Semino-Beninel has been working as Global Regulatory Toxicologist for plant protection products at Bayer CropScience since 1998. She is member of the European Crop Protection Association (ECPA) working groups on cumulative risk assessment.

mehrweniger
Siegrist

Michael Siegrist

ETH Zürich, Switzerland

Michael Siegrist is a Professor for consumer behavior at the Institute for Environmental Decisions (IED) at ETH Zurich. Professor Siegrist’s research focuses on risk perception and risk communication, on acceptance of new technologies and consumer behavior in the food domain.

mehrweniger
Wilks

Martin Wilks

Swiss Centre for Applied Human Toxicology, Switzerland

Martin Wilks is a Medical Toxicologist and risk assessment expert with more than 25 years of experience in academia, industry and the health service. He is Director of the Swiss Centre for Applied Human Toxicology (SCAHT) and Adjunct Professor at the University of Geneva and the University of Basel. He is a EUROTOX Registered Toxicologist, a Fellow of the Royal College of Physicians of Edinburgh, Secretary-General of EUROTOX and President of the European Associations of Poisons Centres and Clinical Toxicologists.

mehrweniger
van Klaveren

Jacob van Klaveren

National Institute for Public Health and the Environment (RIVM), The Netherlands

Jacob van Klaveren has been working for RIVM as a Senior Scientific Advisor since 2010. Currently he coordinates the EFSA-RIVM partnership on the follow-up ACROPOLIS and the EuroMix project. He coordinated the R&D programme on food safety for Wageningen Research, the EU funded ACROPOLIS project and the EuroMix project.

mehrweniger

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