Endocrine Disruptors

The conference dives right into the ongoing debate surrounding the challenging implementation of the ECHA/EFSA guidance for the identification of Endocrine Disruptors and provides participants with all the recent regulatory and scientific developments.

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08.11. — 09.11.2022
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  • Update from the EU Commission on Endocrine Disruptors-related activities concerning REACH and CLP
  • The European Chemicals Agency ECHA on classification and labelling for EDs
  • The German Federal Institute for Risk Assessment (BfR) on ED assessment for human health relevance under PPPR and BPR
  • ED Assessment in the UK post EU Exit, differences to EU guidance
  • Industrial chemicals and endocrine disruptors: REACH and CLP
  • Using ToxCast and the CompTox Chemicals Dashboard as resources to access available endocrine information
  • Optimization of fish test guidelines for endocrine disruption
  • Assessment of methodological issues related to VTG measurements in fish

The ECHA/EFSA guidance for the identification of Endocrine Disruptors in the context of Regulations (EU) No 528/2012 and (EC) No 1107/2009 requires a highly complex and challenging assessment for all active substances. Ever since its publication in June 2018, implementing the requirements has been and will continue to be a challenge. With the proposed introduction of stricter regulation for EDs under the CLP and REACH Regulations, the challenge has recently been broadened. This conference will dive into the debate surrounding Endocrine Disruptors and covers all the relevant recent regulatory and scientific developments.

Who do you meet?

Professionals working in the fields of:

  • Toxicology and ecotoxicology
  • Research and development
  • Registration, regulatory affairs
  • Chemical risk assessment
  • Legal and general counselling

Sectors that should take part:

  • Chemical/biocide/agrochemical/pharmaceutical/cosmetic industries
  • Research institutes
  • Regulatory authorities
  • Environmental and health risk consultants
  • Testing laboratories and contract research organisations (CROs)
  • NGOs

Picture Credit: © Subbotina Anna/shutterstock.com, © chestra - Fotolia.com



PLEASE NOTE: The indicated times refer to Central European Time CET.

For further time zones, please view here.

Thursday, 8 November 2022

Morning Session | 09:30 – 13:10 CET
On-site registration & opening of the virtual meeting room
Welcome address by the organisers and the Chairs

Lennart Weltje, BASF, Germany
Emily McVey, Board for the Authorisation of Plant Protection Products and Biocides (Ctgb), The Netherlands

Regulatory Landscape
Update on Endocrine Disruptors-related activities concerning REACH and CLP

Jordane Wodli, European Commission, Belgium

Classification and labelling for EDs

Kirsi Myöhänen, European Chemicals Agency (ECHA), Finland

Industrial Chemicals and Endocrine Disruptors: REACH and CLP

Heli Hollnagel, Dow Europe, Switzerland

Coffee break
Update on ED-related activities
  • Adverse outcome pathways (AOPs) for endocrine disruptors

Anna Lanzoni, European Food Safety Authority (EFSA), Italy (virtual presentation)

Evaluation of ED assessment for human health relevance under BPR and PPPR: Where are we now?
  • Overview on the ED assessment review process under ECHA and EFSA
  • Obstacles faced
  • Lessons learned

Judy Choi, Federal Institute for Risk Assessment (BfR), Germany

Lunch break

Afternoon Session | 14:30 – 17:35 CET
Endocrine disruptors assessment in the UK post EU Exit, differences to EU guidance
  • Situation in the UK after the EU exit
  • Differences to the EU guidance

Jo Little, Health and Safety Executive, Chemicals Regulation Directorate (HSE/CRD), United Kingdom

Endocrine Disruptors: experiences and challenges
  • Timelines and bottle necks
  • One substance, one assessment (different applicants under different regulations)
  • Risk assessment for EDs – how to apply derogation criteria?
  • National ED programmes
  • Biocidal products including different opinions of MS

Daniela Fruth, knoell Germany, Germany

Coffee break
The no-threshold assumption for EDs: Are the „low-dose effects“ a reproducible scientific fact to guide regulatory toxicology?

Andreas Natsch, Givaudan, Switzerland

Using ToxCast and the CompTox Chemicals Dashboard as resources to access available endocrine information
  • Overview of the estrogen and androgen related models (ToxCast Pathway Models and consensus QSARs)
  • Available information and model for steroidogenesis, based on a high-throughput adaptation of the H295R assay
  • Thyroid-relevant information in ToxCast

Katie Paul Friedman, U.S. Environmental Protection Agency (EPA), United States (virtual presentation)

Final discussion
End of the first day

Wednesday, 9 November 2022

Morning Session | 09:30 – 14:00 CET
Brief welcome by the chairs

Lennart Weltje, BASF, Germany
Emily McVey, Board for the Authorisation of Plant Protection Products and Biocides (Ctgb), The Netherlands

Optimisation of fish test guidelines for endocrine disruption
  • Update from ongoing EU research activities: ERGO and iFEDT project
  • The challenge to identify thyroid-specific adverse effects in fish
  • Implementation of thyroid-related endpoints in existing regulatory guidelines with fish

Lisa Baumann, Heidelberg University, Germany

Thyroid: EDs and human health

Helen Tinwell, Bayer CropScience, France

Test designs for the assessment of thyroid activity and adversity in the African clawed frog Xenopus laevis
  • Applicability domain of existing amphibian test guidelines
  • Optimisation of amphibian test design for thyroid-mediated endocrine activity and adversity
  • Interpretation of biological endpoints and identification of response patterns indicative of thyroid-mediated effects

Laurent Lagadic, Bayer CropScience, Germany

Coffee break
Studies & Methodology
Fish population modelling of Endocrine Disruptors
  • Population models and their use in ED assessments (ECHA / EFSA 2018)
  • Parameterisation of this application of population models
  • How to solve the challenge of using fish population models, chemical toxicity data and exposure profiles for use in a regulatory ED assessment

Charles Hazlerigg, Enviresearch, United Kingdom

Assessment of methodological issues related to VTG measurements in fish

Natalie Burden, NC3R – Reduction Refinement, and Replacement of Animals used in Research, United Kingdom

Anti-androgenicity in fish
  • Uncertainties, raised over the sensitivity of endpoints in fish studies to detect anti-androgenicity
  • Conservation of the androgen receptor between vertebrates and fish species
  • Sensitivity of fish in in vitro and in vivo methodologies to consistently detect model anti-androgenic substances

Grace Panter, CropLife Europe, wca environment, United Kingdom

Final discussion
End of the conference





Lisa Baumann

University of Heidelberg, Germany

Lisa Baumann is a Research Group Leader at the University of Heidelberg. She is specialized in aquatic toxicology with focus on endocrine effects, hepatotoxicity and immunotoxicity in fish. Special focuses of her work are developmental studies with zebrafish (embryos), as well as histopathological analyses. She is part of the EFSA working group for endocrine disruptors.


Natalie Burden

NC3R - Reduction, Refinement, and Replacement of animals used in research, testing, and education, United Kingdom

Natalie Burden is currently a Programme Manager in ecotoxicology at the UK’s NC3Rs. Prior to this she worked in drug discovery at Pfizer and completed a PhD and post-doc in medical research.


Judy Choi

Federal Institute for Risk Assessment (BfR), Germany

Judy Choi is a Certified Toxicologist (DABT, ERT), currently working as a Senior Scientific Officer in the \"Toxicology of Active Substances and their Metabolites\" Unit, Department of Pesticides Safety, at the Federal Institute for Risk Assessment (BfR) in Berlin, Germany. One of her activities at BfR is the toxicological evaluation of active substances for ED potential of human health relevance, and she has been an invited expert in multiple meetings on ED with EFSA or ECHA.


Daniela Fruth

knoell, Germany

Daniela Fruth is a Regulatory Toxicologist at knoell Germany GmbH. She studied food chemistry at the Technical University of Kaiserslautern and is holding a PhD in Pharmacy from the Johannes Gutenberg-University Mainz. After her PhD period spent in the chemical industry focussing on genotoxicity and in vitro metabolism, she joined knoell in 2016 and has since then worked in the biocide sector with a focus on human safety, exposure and risk assessment as well as regulatory affairs. She is part of the knoell ED expert team and is involved in the assessment of active substances (biocides and crop protection) and co-formulants with respect to endocrine disrupting properties


Charles Hazlerigg

Enviresearch, United Kingdom

Charles Hazelrigg is a Senior Ecotoxicologist and UKRI Future Leaders Fellow based at Enviresearch Ltd. He uses ecological modelling approaches to better understand the impacts of chemical stressors on populations, informing decision-making by linking laboratory-generated ecotoxicity data to protection goals.


Heli Hollnagel

Dow Europe, Switzerland

Heli Hollnagel is a EUROTOX registered Toxicologist, working as Regulatory Toxicologist and EMEA Science Leader at Dow Europe. She is also the Chair of Cefic's Polymers Network of Experts and Cefic's LRI Stragetic Implementation Group, as well as a member of the ECETOC Scientific Committee.


Laurent Lag

Bayer CropScience, Germany

Laurent Lagadic works for the Environmental Safety Division of Bayer CropScience in Germany, where he is involved in aquatic risk assessment for pesticides, and currently leads the development and application of testing strategies for evaluating potential endocrine disrupting properties of these substances in aquatic organisms. He holds a PhD in fundamental and environmental toxicology and has previously worked as an Aquatic Ecotoxicologist at the French National Research Institute for Agriculture, Food and Environment (INRAE) for over 20 years.


Anna Lanzoni

European Food Safety Authority (EFSA), Italy (to be confirmed)

Anna Lanzoni is a Senior Scientific Officer at the European Food Safety Authority EFSA. She has previously served as Head of Pathology at Aptuit, a pharmaceutical services provider.


Jo Little

Health and Safety Executive / Chemicals Regulation Division (HSE/CRD), United Kingdom

Jo Little has a background in Biochemistry and joined HSE in 2016 as a Regulatory Toxicologist. After leaving for a short time to work as a Consultant Toxicologist, Jo returned to HSE in July 2021 as a Senior Regulatory Toxicologist. Although working on both pesticide and biocide active Substances and product applications, Jo has overall responsibility at HSE for the toxicology aspects of biocidal active substances and is the technical lead for Endocrine Disruption.


Emily McVey

Board for the Authorisation of Plant Protection Products and Biocides (Ctgb), The Netherlands

Emily McVey is an experienced Regulatory Toxicologist and works as a Risk Assessor in ecotoxicology at the Ctgb. Her specialties include environmental toxicology, wild vertebrates (birds, mammals, amphibians, fish), molecular mechanisms of toxicity, neurodevelopmental toxicity and endocrine disruption testing and assessment.


Kirsi Myöhänen

European Chemicals Agency (ECHA), Finland

Kirsi Myöhänen is a Scientific Officer Unit (C1 Classification) of the European Chemicals Agency ECHA. A toxicologist (PhD Pharm, MSC Pharm, and MSC Tox, European Registered Toxicologist) by trainings, she has been working in ECHA Classification unit from 2012, in ECHA Biocides unit in 2013-2019 with biocidal active substance approval and since 2019 again in classification, where she is currently also involved in developing classification criteria for EDs. Kirsi is also a co-chair of the ECHA Endocrine Disruptor Expert Group (ED EG). She has previously worked as Senior Adviser at the Finnish Safety and Chemicals Agency involved also in developing ED criteria for biocides and PPPs.


Andreas Natsch

Givaudan, Switzerland

Andreas Nastch has over 20 years of research of experience in the fragrance industry. He is currently a Senior Research Fellow with Givaudan in Switzerland, where he is responsible for development and validation of new methods in in vitro toxicology and development of integrated testing strategies (ITS) for skin sensitization testing. He holds a PhD from ETH Zurich and has spent his post doc fellowship at the Centro Nacional de Biotecnologia in Madrid.


Grace Panter

CropLife Europe / wca environment, United Kingdom

Grace Panter joined wca UK in 2018 as an environmental toxicologist and leads on the monitoring of in vitro and higher tier chronic fish and amphibian studies to address regulatory issues, including the assessment of potential endocrine disrupting chemicals. She previously worked at Syngenta conducting environmental risk assessments for PPP for submission in Europe, and worked at the Brixham Environmental Laboratory as a project manager and study director on aquatic projects.

Paul Friedman

Katie Paul Friedman

United States Environmental Protection Agency (US EPA), United States

Katie Paul Friedman joined the National Center for Computational Toxicology in the Office of Research and Development at the US EPA in August 2016, where she is currently focused on integration of multiple information streams to address the needs of preliminary risk assessment, with additional interests in uncertainty in alternative and traditional toxicity information, endocrine bioactivity prediction and in vitro kinetics. Previously, she worked as a Regulatory Toxicologist at Bayer CropScience with specialties in neurodevelopmental and endocrine toxicity, high-throughput science, and predictive toxicology. She has been actively involved in multi-stakeholder projects to develop adverse outcome pathways, alternative testing approaches, and the regulatory acceptance of these tools.


Helen Tinwell

Bayer CropScience, France

Helen Tinwell has a PhD in genotoxicity and joined Bayer Crop Science in 2005 after having spent 17 years at Syngenta. Until recently, she has worked in research toxicology focusing on method development and mode of action investigations to address endocrine disruption. In 2017 she became team leader of the Regulatory Toxicology group. She leads the development and application of testing strategies for evaluating potential endocrine-disrupting properties of plant protection molecules in mammals and is a member of the ECPA ED Expert Group.


Lennart Weltje

BASF, Germany

Lennart Weltje holds a PhD in ecotoxicology and environmental chemistry and currently works as a Senior Ecotoxicologist at BASF conducting risk assessments for PPPs and biocides. He is also an honorary Professor at the Faculty of Agricultural Sciences of the Georg-August University in Goettingen. His former stations include the Dutch National Institute for Public Health and the Environment (RIVM).


Jordane Wodli

European Commission, Belgium

Jordane Wodli currently serves as a policy advisor national expert on chemicals in the European Commission’s DG Environment.



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